The Moradali Lab

NEWS & Research updates

We are currently exploring a novel immune signaling system in monocyte cell models that governs the production of type I interferons (IFNs) in response to microbial immunostimulatory factors. While the type I IFN response is well-characterized in viral infections, its precise role in bacterial colonization, bacterial infections, and co-infections involving both viruses and bacteria remains largely unexplored. Our research aims to unravel the molecular mechanisms by which monocytes detect and respond to microbial signals, shedding light on how this immune pathway influences host defense in complex infectious and inflammatory conditions. Understanding this interplay could provide new insights into host immunity and identify potential therapeutic targets for infectious diseases involving mixed microbial communities.

For general audience

We are studying how immune cells called monocytes respond to microbes and help fight infections. Specifically, we are investigating a molecular signaling system that controls the production of immune proteins called type I interferons (IFNs). These proteins are well-known for their role in fighting viruses, but their function in bacterial infections and mixed infections (bacteria and viruses together) is not well understood. Our research aims to uncover how monocytes detect microbes and how this immune response affects our body’s defense against infections or contributes to chronic and systemic inflammations. This could lead to new ways to treat infectious diseases.

University of Louisville School of Dentistry, Department of Oral Immunology and Infectious Diseases, Louisville, KY 40202
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