The Moradali Lab

NEWS & Research updates

We are currently investigating a novel immune signaling system in monocytes and dendrtitic cells that regulates the production of type I interferons (IFNs) in response to microbial immunostimulatory factors. While the type I IFN response is well-characterized in viral infections, autoimmune diseases, and cancers, its precise role in microbe-driven infections and inflammation remains largely unexplored. Our research aims to unravel the molecular mechanisms by which monocytes and dendritic cells detect and respond to mixed microbial signals, providing insight into how type I IFN signaling influences host defense in complex infectious and inflammatory conditions. Understanding this interplay could offer new perspectives on host immunity and identify potential therapeutic targets for infectious diseases involving mixed microbial communities.

For general audience

We are studying how immune cells called monocytes and dendritic cells respond to microbes and help fight complex infections. Specifically, we are investigating a molecular signaling system that controls the production of immune proteins called type I interferons (IFNs). These proteins are well-known for their role in viral infections, autoimmune diseases, and cancers, but their function in chronic infections and inflammations is not well understood. Our research aims to uncover how these immune cells detect mixed signals and how this immune response affects our body’s defense against infections or contributes to chronic and systemic inflammations. This could lead to new ways to treat chronic diseases.

University of Louisville School of Dentistry, Department of Oral Immunology and Infectious Diseases, Louisville, KY 40202
[[email protected]]